Hexahydrocannabidiol, or H4CBD, is a synthesized cannabinoid created by adding four hydrogen atoms to the CBD molecule. The process used to make H4CBD is very similar to making margarine from vegetable oil.
H4CBD is one of the newest cannabinoids to enter the market, but it’s already making waves as a slightly stronger, quasi-intoxicating form of CBD
Studies have shown that H4-CBD can help reduce anxiety and stress levels in both animals and humans. One study published in the Journal of Psychopharmacology found that H4-CBD reduced anxiety and improved cognitive function in participants with social anxiety disorder. Another study published in the Journal of Clinical Psychopharmacology found that H4-CBD reduced anxiety in patients with generalized anxiety disorder.
H4CBD interacts with the body's endocannabinoid system (ECS), a complex cell-signaling system that helps to regulate various physiological processes such as mood, appetite, pain, and inflammation. The ECS consists of three main components: endocannabinoids (cannabinoids produced by the body), receptors (proteins that bind to cannabinoids), and enzymes that break down cannabinoids.
H4CBD contains a combination of cannabinoids and terpenes that interact with the ECS in several ways. The cannabinoids in H4CBD interact with both the CB1 and CB2 receptors in the ECS. CBD has a low affinity for these receptors. H4CBD may also interact with other receptors in the body that are not directly part of the ECS, such as the serotonin and vanilloid receptors. These interactions may contribute to the potential therapeutic effects of H4CBD for conditions such as anxiety, depression, and pain.
The terpenes in H4CBD, including myrcene, may also interact with the ECS by enhancing the permeability of the blood-brain barrier, allowing other compounds to cross more easily and potentially enhancing the effects of the cannabinoids in H4CBD.
The combination of cannabinoids and terpenes in H4CBD may provide a more comprehensive approach to interacting with the ECS than any one of these compounds alone.
H4CBD is a natural product that has shown promise in supporting neuro-protection. Neuro-protection refers to the preservation of neuronal function and structure in the brain and nervous system, and it is important for maintaining overall brain health and cognitive function. Here are some ways in which H4CBD can help support neuroprotection:
Reducing Oxidative Stress: H4CBD has been shown to have antioxidant properties, which may help to reduce oxidative stress in the brain. Oxidative stress is a process that occurs when there is an imbalance between the production of free radicals and the body's ability to neutralize them. This can lead to damage to the brain cells, which can contribute to cognitive decline and other neurological disorders. H4CBD's antioxidant properties may help to protect the brain cells from oxidative stress.
Reducing Inflammation: Chronic inflammation can also lead to damage to the brain cells, which can contribute to cognitive decline and other neurological disorders. H4CBD has been shown to have anti-inflammatory properties, which may help to reduce inflammation in the brain and protect the brain cells from inflammation-related damage.
Regulating Neurotransmitters: H4CBD has been shown to interact with the body's endocannabinoid system (ECS), which plays a role in regulating neurotransmitters in the brain. Neurotransmitters are chemical messengers that transmit signals between neurons, and imbalances in neurotransmitters can contribute to neurological disorders. H4CBD's interaction with the ECS may help to regulate neurotransmitters and support overall brain health.
Promoting Neurogenesis: Neurogenesis refers to the process of generating new neurons in the brain, and it is important for maintaining cognitive function and overall brain health. H4CBD has been shown to have potential neurogenesis-promoting effects, which may help to support neuroprotection.
Supporting Mitochondrial Function: Mitochondria are the powerhouses of the cells, and they play a critical role in energy production and cellular function. Dysfunction in mitochondria can contribute to neurological disorders. H4CBD has been shown to have potential mitochondria-supporting effects, which may help to support overall brain health.
H4-CBD has been shown to have fewer side effects than traditional anti-anxiety medications.
For example, benzodiazepines are commonly prescribed for anxiety, but they can be addictive and can cause drowsiness, dizziness, confusion, and impaired coordination. They can also have negative interactions with other medications, including opioids and alcohol, which can increase the risk of overdose
Similarly, selective serotonin reuptake inhibitors (SSRIs) are often prescribed for anxiety, but they can cause a range of side effects such as nausea, vomiting, diarrhea, insomnia, and sexual dysfunction. Additionally, some patients may not respond well to SSRIs or may experience withdrawal symptoms when discontinuing use.
H4-CBD has been shown to have a favorable safety profile, with few side effects.
H4-CBD works by interacting with the body's endocannabinoid system (ECS), it may have a more targeted and specific effect on anxiety symptoms, without the widespread effects on the body that traditional anti-anxiety medications can have.
Yes, H4CBD is technically synthetic. Keep in mind that this hydrogenated cannabinoid has not been artificially constructed from scratch or combined with any complicated substances. Nonetheless, any alteration in a natural compound is considered a synthetic form of the original. Also, synthesized versions of substances almost always have new and unique properties.
The claim that H4-CBD is 100 times stronger than conventional CBD is more hype than it is fact. Based on a single unreproduced study from more than 15 years ago, scientists now speculate that H4-CBD may demonstrate remarkably increased affinity compared to CBD
No, H4-CBD does not get you high. While H4-CBD is a cannabinoid and is derived from the same plant as marijuana, it does not produce the "high" or intoxicating effects associated with THC. H4CBD interacts with the body's endocannabinoid system differently than THC, and it does not bind to the same receptors in the brain that are responsible for producing the euphoric effects of THC.
CBD and H4CBD are not same. CBD and H4-CBD have different chemical structures. CBD has a straight, flat structure, while H4-CBD has a more complex, ringed structure. This difference in structure affects how the compounds interact with the body's endocannabinoid system. H4-CBD is more potent than CBD, meaning it may be more effective at lower doses.
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